Giovanni Domenico de Cupis (Cupi, Cuppi) (1493–1553) was an Italian Cardinal, created by Pope Leo X in the consistory of 1 July 1517.
Biography He was Crown-cardinal of the Kingdom of Scotland. He was a friend of Ignatius Loyola.Sede Vacante 1549-1550
His mother was Lucrezia Normanni, who had had a daughter Felice della Rovere by Pope Julius II before marrying Bernardino de Cupis, Giovanni Domenico's father. He owed early advancement as Bishop of Trani to Julius.Caroline Murphy, The Pope's Daughter: The Extraordinary Life of Felice Della Rovere (2005), p. 162.
He was Bishop of Albano in 1531, Bishop of Sabina in 1532, Bishop of Porto e Santa Rufina in 1535 and Bishop of Ostia in 1537. Dean of the College of Cardinals in 1541.
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