CD7

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.

Function This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

See also Cluster of differentiation DC-7

Interactions CD7 has been shown to interact with PIK3R1.

Clinical significance CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).

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