SMSC may refer to:
Organizations Seoul Metropolitan Subway Corporation, now merged into Seoul Metro, South Korea Southwest Minnesota State College, US, now a university Standard Microsystems Corporation, a company acquired by Microchip Technology Smithsonian-Mason School of Conservation, Virginia, US, a partnership between George Mason University and the Smithsonian Institution
Other uses Shakopee Mdewakanton Sioux Community, a tribe of Dakota people in Minnesota, US Short message service center, in the mobile telephone network Spiritual, moral, social and cultural development, provided in schools through the National Curriculum for England