AM-905 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors. It is a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2 nM at CB1 and 5.3 nM at CB2.
See also 1,2-Didehydro-3-oxo-THCO AM-906 - The corresponding Z or cis isomer HU-243 - Double bond replaced by geminal methyls for Thorpe–Ingold effect
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