OPC may refer to:

Architecture and engineering Optical proximity correction Ordinary Portland cement Organic Photo Conductor, an element used for, among other applications, photocopier and laser printer drums.

Computing Open Packaging Conventions, a container-file technology created by Microsoft to store a combination of XML and non-XML files Open Platform Communications (formerly "OLE for Process Control") OPC Foundation, a related consortium Operations Planning and Control, from Tivoli Software, known as IBM Tivoli Workload Scheduler Optimized Power Control, a method to adjust laser power when writing optical media. Other peoples' computers, reference to privacy issues of cloud computing data being on somebody else's computer rather than your own and potential security issues.

Medicine and natural sciences Ocean Prediction Center Oligodendrocyte precursor cell Oligomeric proanthocyanidin Oropharyngeal cancer

Social matters, politics and government Obama Presidential Center (Federal) Office for the Protection of the Constitution, a translation of the German name Bundesamt für Verfassungsschutz Office of Policy Coordination, a secret U.S. government unit, 1948–1952 Office of the Parliamentary Counsel (United Kingdom) Office of the Privacy Commissioner of Canada Online Party of Canada Ontario Progressive Conservative Party, Conservative political party in the province of Ontario Oodua Peoples Congress, militant Yoruba nationalist organization situated in Nigeria Organisation pour la prévention de la cécité (Organisation for the Prevention of Blindness), a French blindness charity working in Africa Orthodox Presbyterian Church, a confessional Reformed Christian denomination Ottawa People’s Commission on the Convoy Occupation, Ontario, Canada Overseas Press Club, a journalists' organization in New York City Overdose prevention centers, otherwise known as Supervised injection sites

Other Offshore Patrol Cutter Ontario Police College O-Pee-Chee, a Canadian sports card company Ontario Pioneer Camp, in Huntsville, Ontario, Canada Opel Performance Center, a division of car manufacturer Opel Optional Payment Charge, a surcharge applied when paying by credit card for airline flights Organic photoconductor drum, used in photocopiers and printers One Person Company, a category of Limited company