Luis Guzmán (born 1956) is a Puerto Rican actor.
Luis Guzmán may also refer to:
Luis Guzmán (Spanish footballer) (1893–1942), Spanish football forward Luis Guzmán (Peruvian footballer) (1918–1989), Peruvian football midfielder Luis Guzmán Canoura (1924–?), Chilean businessman and politician Luis Guzmán (water polo) (born 1945), Mexican Olympic water polo player
Luis Enríquez de Guzmán, 9th Count of Alba de Liste (born c. 1605), viceroy of New Spain and Peru Luis Muñoz de Guzmán (1735–1808), Spanish colonial administrator Luis Roberto Guzmán (born 1973), Puerto Rican actor
See also Luisa de Guzmán (1613–1666), Spanish noblewoman