This page provides supplementary chemical data on Cocaine in free base form. More commonly available "powder cocaine" is a hydrochloride salt whose properties will differ.

Material Safety Data Sheet

The handling of this chemical may incur notable safety precautions. It is highly recommend that you seek the Material Safety Datasheet (MSDS) for this chemical from a reliable source such as SIRI, and follow its directions.

Structure and properties

Structure and properties Index of refraction, nD 1.5022 Abbe number ? Dielectric constant, εr ? ε0 at ? °C Bond strength ? Bond length ? Bond angle ? Magnetic susceptibility ? Melting point 98 °C Boiling point 187 °C Solubility 1.7 g/L at 25 °C

Thermodynamic properties

Phase behavior Triple point ? K (? °C), ? Pa Critical point ? K (? °C), ? Pa Std enthalpy changeof fusion, ΔfusHo ? kJ/mol Std entropy changeof fusion, ΔfusSo ? J/(mol·K) Std enthalpy changeof vaporization, ΔvapHo ? kJ/mol Std entropy changeof vaporization, ΔvapSo ? J/(mol·K) Solid properties Std enthalpy changeof formation, ΔfHosolid ? kJ/mol Standard molar entropy,Sosolid ? J/(mol K) Specific heat capacity, cp ? J/(mol K) Liquid properties Std enthalpy changeof formation, ΔfHoliquid ? kJ/mol Standard molar entropy,Soliquid ? J/(mol K) Specific heat capacity, cp ? J/(mol K) Gas properties Std enthalpy changeof formation, ΔfHogas ? kJ/mol Standard molar entropy,Sogas ? J/(mol K) Specific heat capacity, cp ? J/(mol K)

Spectral data

UV-Vis λmax ? nm Extinction coefficient, ε ? IR Major absorption bands ? cm−1 NMR Proton NMR   Carbon-13 NMR   Other NMR data   MS Masses of main fragments  

External links Nuclear magnetic resonance and molecular orbital study of some cocaine analogues, includes superposition and overlay of cocaine, cocaine derivatives, and their minimum energy values. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation, thorough-going elucidation of exact mechanism and mode of action specific to cocaine at the dopamine transporter. Genome Wide Analysis of Chromatin Regulation by Cocaine Reveals a Novel Role for Sirtuins

References