Isetemkheb D was the sister-wife of the Theban High Priest of Amun Pinedjem II during the Twenty-first Dynasty of Egypt.

Family Isetemkheb D was the daughter of the King's Son, Theban High Priest of Amun and General, Menkheperre, and his wife, Isetemkheb C. Isetemkheb D married her brother Pinedjem II.

Isetemkheb and Pinedjem II are thought to have had four children:Aidan Dodson & Dyan Hilton, The Complete Royal Families of Ancient Egypt, Thames & Hudson (2004) Andrzej Niwinski: The Wives of Pinudjem II: A Topic for Discussion: The Journal of Egyptian Archaeology Vol. 74 (1988), pp. 226-230 Theban High Priest of Amun and Pharaoh Psusennes II (Pasebakhaenniut II), Lady Harweben, who was a Chief of the Harem of Amen-Re God's Wife of Amun Hennutawy Lady of the House and Chantress Maatkare.

Burial Isetemkheb's mummy and coffins were found in the royal cache found in TT320 in Deir el-Bahari in Thebes. Istemkheb's mummy was never unwrapped.Isetemkheb D's Burial in TT320 from the Theban Royal Mummy Project by Max Miller

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