Rafael Nadal defeated defending champion Novak Djokovic in a rematch of the previous year's final, 7–5, 6–3 to win the men's singles tennis title at the 2012 Italian Open. It was his record-extending sixth Italian Open title. He did not lose a set during the tournament.
Seeds The top eight seeds receive a bye into the second round.
Novak Djokovic (final) Rafael Nadal (champion) Roger Federer (semifinals) Andy Murray (third round) Jo-Wilfried Tsonga (quarterfinals) David Ferrer (semifinals) Tomáš Berdych (quarterfinals) Janko Tipsarević (second round) John Isner (second round) Juan Martín del Potro (third round) Gilles Simon (third round) Nicolás Almagro (third round) Gaël Monfils (second round) Juan Mónaco (third round) Feliciano López (first round) Richard Gasquet (quarterfinals)
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
References Main Draw Qualifying Draw