Tryphaena or Tryphena may refer to:
Tryphaena Tryphaena (ca 141 BC – 111 BC), Ptolemaic princess, wife of Antiochus VIII Grypus, queen of Syria Saint Tryphaena of Cyzicus (fl. 1st century AD), Roman Christian martyr Crepereia Tryphaena, Roman woman discovered with grave goods in 1889 Tryphaena Cleopatraina may refer to: Cleopatra V Tryphaena Cleopatra VI Tryphaena Antonia Tryphaena (10 BC – 55), Queen of Thrace, likely the basis of Tryphena in Romans and in The Acts of Thecla and Paul Tryphaena, a character in the Satyricon of Petronius
Tryphena Tryphena and Tryphosa, women mentioned in Romans 16 Tryphena Anderson (born 1933), Jamaican-British nurse, the first black health visitor in the United Kingdom Tryphena Sparks (1851–1890), a cousin and possible lover of Thomas Hardy Tryphena, New Zealand, a town in New Zealand