Cristoforo Colombo (1451–1506) was a European explorer better known as "Christopher Columbus".

Cristoforo Colombo may also refer to:

Cristoforo Colombo (opera), an 1892 opera in four acts and an epilogue by Italian Alberto Franchetti SS Cristoforo Colombo, an Italian ocean liner built in the 1950s Italian corvette Cristoforo Colombo (1892), an Italian unprotected corvette Italian school ship Cristoforo Colombo (1926), an Italian tall ship, later Dunay in the Soviet Navy Via Cristoforo Colombo, a road in Rome named for Christopher Columbus Genoa Cristoforo Colombo Airport, airport of Genoa, Italy

See also Christopher Columbus (disambiguation) Cristoforo (given name)