Hofheimer is a surname. Notable people with the surname include:
Meister Pauls Hoffheimer, a.k.a. Paul Hofhaimer, Paulus Hofhaymer etc. (1459–1537), Austrian composer Aline Rhonie Hofheimer (1909–1963), American aviator Charlie Hofheimer (born 1981), American film, television and theatre actor Grace Hofheimer (1891–1965), American pianist
See also Hofheimer's, American retail company, now defunct