4-hydroxycoumarin synthase (, BIS2, BIS3) is an enzyme with systematic name malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase. This enzyme catalyses the following chemical reaction
malonyl-CoA + 2-hydroxybenzoyl-CoA 2 CoA + 4-hydroxycoumarin + CO2
This polyketide synthase can also accept benzoyl-CoA as substrate.
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