Ordzhonikidze or Orjonikidze () is a Georgian surname which may refer to:
Ordzhonikidze Grigoriy Ordzhonikidze (better known as Sergo Ordzhonikidze) (1886–1937), Georgian Bolshevik and Soviet political leader Sergei Ordzhonikidze, Russian diplomat Lika Ordzhonikidze, Georgian model
Orjonikidze Mindora Orjonikidze (1879—1967), Georgian politician Iza Orjonikidze, Georgian poet and politician