Frist is a surname. Notable people with the surname include:

Bill Frist (born 1952), American physician, businessman, and politician Patricia C. Frist, American businesswoman and philanthropist Thomas F. Frist, Jr. (born 1938), American billionaire physician and businessman Thomas F. Frist, Sr. (1910–1998), American physician and businessman Thomas F. Frist III, American businessman William R. Frist, American businessman

See also Frist Art Museum, Nashville, Tennessee Frist Campus Center, Princeton University, New Jersey