Zakharyan is a surname. Notable people with the surname include:
Arsen Zakharyan (born 2003), Russian football player Vanik Zakharyan (1936–2023), Armenian academic Yervand Zakharyan (born 1946), Armenian politician
The rulers of the Zakarid dynasty were known as Zakarians. They include:
Avag Zakarian Avag-Sargis III Zakarian Ivane I Zakarian Ivane II Zakarian Khoshak Zakarian Khosrov Zakarian Sargis Zakarian Shahnshah Zakarian Shahnshah II Zakarian Tamta Mkhargrdzeli, or Tamta Zakarian Zakare I Zakarian Zakare II Zakarian Zakare III Zakarian