The D'Una River () is a river of the state of Santa Catarina, Brasil.
Course The D'Una rises in the Serra do Tabuleiro State Park. The lush forests of the park protect the sources of the Vargem do Braço, Cubatão and D'Una rivers, which supply most of the drinking water for greater Florianópolis and the south coast region. The river runs south into the Lagoa do Imaruí, which empties into the Atlantic Ocean beside Laguna, Santa Catarina.
See also List of rivers of Santa Catarina List of rivers of Brazil
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