DeWeese is a surname. Notable people with the surname include:
Bill DeWeese (born 1950), American politician Bob DeWeese (artist) (1920-1990), American painter Bob DeWeese (politician) (1934-2020), American politician Bob DeWeese (basketball) (1915–1991), American basketball player Devin Deweese (1835–1906), American historian Ebby DeWeese (1904–1942), American football player Gene DeWeese (1934–2012), American writer Gennie DeWeese (1921–2007), American painter John T. Deweese (1835–1906), American politician Mary Ann DeWeese (1913–1993), American designer Theodore DeWeese, American radiation oncologist and academic administrator
See also Deweese, Nebraska DeWeese Reservoir