Big Run may refer to:
Big Run, Ohio Big Run, Jefferson County, Pennsylvania Big Run, Marion County, West Virginia Big Run, Marshall County, West Virginia Big Run, Webster County, West Virginia Big Run, Wetzel County, West Virginia Big Run (East Branch Fishing Creek), in Sullivan County, Pennsylvania Big Run (Little Muncy Creek), in Lycoming County, Pennsylvania Big Run (South Branch Potomac River), in Hampshire County, West Virginia Big Run (West Branch Fishing Creek), in Sullivan County, Pennsylvania Big Run (Slippery Rock Creek tributary), in Butler County, Pennsylvania Big Run, a 1989 arcade game developed by Jaleco