De Fleury is a surname. Notable people with the surname include:
André-Hercule de Fleury (1653–1743), chief minister of Louis XV of France, cardinal and Bishop of Fréjus Charles Rohault de Fleury (1801–1875), French architect François de Fleury (1749–1799), French officer who fought in the American Revolutionary War Georges Rohault de Fleury (1835–1904), French archaeologist and art historian Hubert Rohault de Fleury (architect) (1777–1846), French architect Hubert Rohault de Fleury (soldier) (1779–1866), French general Hubert Rohault de Fleury (painter) (1828–1910), French painter Joseph Omer Joly de Fleury (1715–1810), French opponent of the Encyclopédie, Jesuits and inoculation Maria De Fleury (fl. 1773–1791), London Baptist poet, hymnist and polemicist
See also Fleury (name), a surname and given name