The 1959 Pepperdine Waves football team represented George Pepperdine CollegePepperdine University was known as George Pepperdine College from 1937 to 1970. as an independent during the 1959 college football season. The team was led by fifth-year head coach John Scolinos. For the 1959 season, the Waves moved home games back to Sentinel Field on the campus of Inglewood High School in Inglewood, California. They had previously played at Sentinel Field in 1946, 1947, and 1949. Pepperdine finished the season with a record of 2–5–1.

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