For much of his adult life, Charles Darwin's health was repeatedly compromised by an uncommon combination of symptoms, leaving him severely debilitated for long periods of time. However, Darwin himself suggested that, in some ways, this may have helped his work: "Even ill-health, though it has annihilated several years of my life, has saved me from the distractions of society and amusement."

Darwin consulted numerous doctors, but, with the medical science of the time, the cause remained undiagnosed. He tried all available treatments, but these had at best only temporary success. More recently, there has been much speculation as to the nature of his illness.

It has been suggested that exhuming Darwin's remains could clarify the nature of his health issues.

Development of illness and symptoms

As a medical student at the University of Edinburgh, Darwin found that he was too sensitive to the sight of blood and the brutality of surgery at the time, so he turned his attention to natural history, an extramural interest he developed when studying at the University of Cambridge to qualify as a clergyman.

On 10 December 1831, as he waited in Plymouth for the voyage on HMS Beagle to begin, he suffered from chest pain and heart palpitations, but told no one at the time in case it stopped him from going on the survey expedition., During the voyage, he suffered badly from sea-sickness during the eighteen months he was at sea, but he spent much of the three years and three months he was on land in strenuous exploration. In Argentina at the start of October 1833, he collapsed with a fever. He spent two days in bed, and then memories of a young shipmate who had died of the fever persuaded him to take a boat down river to Buenos Aires, lying ill in his cabin until the fever passed.

On 20 September 1834, while returning from a horseback expedition in the Andes mountains, he fell ill and spent the month of October in bed in Valparaíso. This would be consistent with infection with Trypanosoma cruzi, which causes Chagas disease. In his diary for 25 March 1835, while to the east of the Andes near Mendoza, he noted "an attack (for it deserves no less a name) of the Benchuca, a species of Reduvius, the great black bug of the Pampas". These are associated with transmittal of Trypanosoma cruzi causing Chagas' disease, but in subsequent days he does not mention the fever characteristic of first infection, which may have occurred in September 1834.

After the voyage ended on 2 October 1836, he quickly established himself as an eminent geologist, at the same time secretly beginning speculations on transmutation as he conceived of his theory. On 20 September 1837, he suffered "an uncomfortable palpitation of the heart" and as "strongly" advised by his doctors, left for a month of recuperation in the countryside. That October he wrote, "Of late anything which flurries me completely knocks me up afterwards, and brings on a violent palpitation of the heart." letter to Henslow, 14 October 1837. In the spring of 1838 he was overworked, worried and suffering stomach upsets and headaches which caused him to be unable to work for days on end. These intensified and heart troubles returned, so in June he went "geologising" in Scotland and felt fully recuperated. Later that year however, bouts of illness returned—a pattern which would continue. He married Emma Wedgwood on 29 January 1839, and in December of that year as Emma's first pregnancy progressed, he fell ill and accomplished little during the following year.

For over forty years Darwin suffered intermittently from various combinations of symptoms such as: malaise, vertigo, dizziness, muscle spasms and tremors, vomiting, cramps and colics, bloating and nocturnal intestinal gas, headaches, alterations of vision, severe tiredness, nervous exhaustion, dyspnea, skin problems such as blisters all over the scalp and eczema, crying, anxiety, sensation of impending death and loss of consciousness, fainting, tachycardia, insomnia, tinnitus, and depression.

Water treatment Darwin had no success with conventional treatments. In 1849, after about four months of incessant vomiting he took up the recommendation of his friend Captain Sulivan and cousin Fox to try the water therapy regimen at Dr James Gully's Water Cure Establishment at Malvern. He read Gully's book, which provided case histories and had a price list at the back. Darwin rented a villa at Malvern for his family and started a two-month trial of the treatment on 10 March. Gully agreed with Darwin's self-diagnosis of nervous dyspepsia and set him a routine including being heated by a spirit lamp until dripping with perspiration, then vigorous rubbing with cold wet towels and cold foot baths, a strict diet, and walks. Darwin enjoyed the attention and the demanding regime which left him no time to feel guilty about not working. His health improved rapidly, and he felt that the water cure was "no quackery".Letter 1236 – Darwin, C. R. to Hooker, J. D., 28 Mar 1849. Darwin Correspondence Project, accessed on 11 April 2019. He had no faith in the homeopathic medicines Gully gave him three times a day but took them obediently.Letter 1234 – Darwin, C. R. to Darwin, S. E., 19 Mar 1849 Darwin Correspondence Project, accessed on 11 April 2019. They stayed on until 30 June, and back home at Down House, he continued with the diet and with the water treatment aided by his butler. He followed the rules about rising early and rationing his working time and had the Sandwalk constructed in the grounds for his walking exercise, setting a routine which he continued.

In September, his sickness returned during the excitement of a British Association for the Advancement of Science meeting, and Darwin made a day visit to Malvern, then recuperated at home. In June 1850, after losing time to illness (without vomiting), he spent a week at Malvern. Later that year he wrote to Fox about the credulity of his "beloved Dr Gully" who when his daughter was ill, treated her with a clairvoyant girl to report on internal changes, a mesmerist to put her to sleep, John Chapman as homeopathist and himself as hydropathist, after which Gully's daughter recovered. Darwin explained to Fox his wrathful scepticism about clairvoyance and worse, homeopathy, thinking the infinitesimal doses were against all common sense and should be compared against the effects of no treatment at all. Gully had pestered Darwin to subject himself to clairvoyance, and when he saw the clairvoyant, he tried to test her by asking her to read the number on a banknote he had in an envelope, but she scornfully said this was something her maidservant did and proceeded to diagnose horrors in Darwin's insides, a tale he recounted for years afterwards.Letter 1352 – Darwin, C. R. to Fox, W. D., 4 Sept 1850 Darwin Correspondence Project, accessed on 11 April 2019. When Darwin's own young daughter Annie had persistent indigestion, he confidently took her to Gully on 24 March 1851 and after a week, left her there to take the cure but a fortnight later was recalled by Dr. Gully as Annie had bilious fever. Dr. Gully was attentive and repeatedly reassured them that she was recovering, but after a series of crises, Annie died on 23 April. Darwin was heartbroken at this tragic loss, but surprisingly stayed well in the aftermath, busy with organising the funeral arrangements.

Darwin kept records of the effects of the continuing water treatment at home and in 1852 stopped the regime, having found that it was of some help with relaxation but overall had no significant effect, indicating that it served only to decrease his psychosomatic symptomatology.

With the memories of Annie's death, Darwin did not want to return to Malvern. In 1856, he began writing for publication of his theory, and he pressed on, overworking, until by March 1857 illness was cutting his working day "ridiculously short". He found a new hydrotherapist, Dr. Edward Wickstead Lane, whose Moor Park hydropathic establishment near Farnham in Surrey was only 40 miles from Darwin's home. His condition was much as when Darwin had first seen Gully, and Dr. Lane later wrote, "I cannot recall any [case] where the pain was as poignant as his. When the worst attacks were on, he seemed crushed with agony." Darwin arrived on 22 April and wrote to Fox that "it is really quite astonishing & utterly unaccountable the good this one week has done me", deciding to stay on to 5 May. He enjoyed the more relaxed regime, which did not include clairvoyance, mesmerism or homeopathy, as Lane did "not believe in all the rubbish which Dr G. does." Darwin became a complete convert, "well convinced that the only thing for Chronic cases is the water-cure", and wrote, "I really think I shall make a point of coming here for a fortnight occasionally, as the country is very pleasant for walking." He told Hooker he had "already received an amount of good, which is quite incredible to myself & quite unaccountable.—I can walk & eat like a hearty Christian; & even my nights are good.—I cannot in the least understand how hydropathy can act as it certainly does on me. It dulls one's brain splendidly, I have not thought about a single species of any kind, since leaving home." He then contradicted himself by asking about alpine species.,

He returned to Moor Park from 16 to 29 June and 5–12 November 1857 and from 20 April to 3 May 1858, but this retreat was unavailable when he was shocked by receipt of Wallace's paper on 18 June, as Dr. Lane was put on trial accused of adultery with a lady patient. Darwin was able to resume treatment at Moor Park from 25 to 31 October 1858, as he struggled on to write On the Origin of Species despite repeated health problems. He was able to keep writing thanks to visits to the spa on 5–18 February, 21–28 May and 19–26 July 1859.

With the proofs of the book returned to the printers, he was worn out. On 2 October, he left for Ilkley and had treatment at Wells House hydropathic establishment operated by Dr. Edmund Smith, a surgeon and hydropathic doctor. Emma brought their children on 17 October, and the family including Darwin stayed in North House, Wells Terrace, which he rented. Reading the first adverse reviews there, his health worsened with a sprained ankle followed by a swollen leg and face, boils and a rash. He had an "odious time", and wrote of Smith that "he constantly gives me impression, as if he cared very much for the Fee & very little for the patient". By 6 November, he felt worse than when he came. Emma and the children went home on 24 November. Darwin stayed on in the establishment, and for the last ten days of the stay, he felt much better. He returned home on 7 December, and under pressure of work, his health slipped back a bit.

As arguments continued, Darwin had more stomach upsets, and on 28 June 1860, two days before the famous 1860 Oxford evolution debate, he fled to Lane's new hydropathic establishment at Sudbrooke Park, Petersham, near Richmond in Surrey and recuperated as well as reading reports of the debate.

Darwin avoided further hydropathy, perhaps recalling his time at Ilkley, and Lane left the business for a while after selling Sudbrooke Park. In 1863, Darwin's illness worsened seriously, and Emma Darwin persuaded her husband to return to Malvern. His cousin Fox had earlier told him that Gully had suffered a mental breakdown and was unavailable. They arrived on 2 September, but Darwin felt that he was being fobbed off with the supervising physician, Dr. Ayerst. Emma arranged for Dr. Gully to attend and endorse Ayerst's treatment, but by then Darwin's eczema was too raw to bear any water. Darwin had a complete breakdown and on 13 October, left the spa worse than when he arrived. His ill health was the worst he had ever experienced and continued until the start of 1866.

Continuing illness