Lesher is a surname. Notable people with the surname include:
Brian Lesher (born 1971), Belgian baseball player Dean Lesher (1903–1993), American newspaper publisher Edgar J. Lesher (1914–1998), American aircraft designer John Lesher (producer) (born 1966), American film producer John Vandling Lesher (1866–1932), American politician Michael Lesher (born 1951), American geologist Robert O. Lesher (born 1921), American judge