Deborah James may refer to:
Deborah James (activist) (born 1971), American activist Deborah James (anthropologist) (born 1954), South African anthropologist Deborah James (journalist) (1981–2022), English journalist and podcast host Deborah Lee James (born 1958), American public servant who served as the 23rd Secretary of the Air Force Deborah James (sprinter) (born c. 1964), NCAA champion sprinter for the Nebraska Cornhuskers track and field team