Trois-Pistoles is a city in Quebec, Canada.

Trois-Pistoles or Trois Pistoles may also refer to:

Trois Pistoles River in Bas-Saint-Laurent, Quebec Trois Pistoles station, a train station in the Quebec city Trois Pistoles (ale), an ale brewed by Unibroue

See also "Three Pistols", a 1991 song by The Tragically Hip Pistole