Reilly Opelka defeated John Isner in the final, 6–3, 7–6(9–7), to win the singles tennis title at the 2022 U.S. Men's Clay Court Championships. It marked Opelka's fourth career Association of Tennis Professionals (ATP) singles title and his first on clay. With Opelka's height at and Isner's at , the combined heights of both players made the final the tallest one ever contended during the Open Era. At the age of 36, Isner was also playing to become the oldest champion at the tournament in the Open Era.
Cristian Garín was the defending champion from when the tournament was last held in 2019, but lost in the semifinals to Isner.
Seeds The top four seeds received a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying Seeds
Qualifiers
Lucky losers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw