Prasain or Prasai () is a surname belonging to the Khas people of both the Brahmin and Chhetri caste from Nepal.

Notable people with the surname Prasain include: Deepika Prasain, Nepalese movie and theater actress Ganga Prasad Prasain, Indian politician Bishnu Prasad Prasain, Nepali politician Khanuparude (Rambabu Prasai), Nepali politician Nanda Kumar Prasai, Nepali politician Durga Prasai , Nepali businessman References