Diéguez is a surname. Notable people with the surname include:
Adrián Diéguez (born 1996), Spanish footballer José Diéguez Reboredo (1934–2022), Spanish Roman Catholic prelate Margarita Diéguez Armas, Mexican diplomat Míriam Diéguez (born 1986), Spanish footballer Rosario Hernández Diéguez (1916–1936), Spanish Galician newspaper hawker and trade unionist