Mafileo is a given name and surname. Notable people with the name include:
Mafileo Kefu (born 1983), Australian rugby union footballer Simana Mafileo (born 1969), Tongan rugby union player Sione Mafileo (born 1993), New Zealand rugby union player Tevita Mafileo (born 1998), New Zealand rugby union player Salote Mafileʻo Pilolevu Tuita (born 1951), Tongan princess