25T-NBOMe, also known as 2C-T-NBOMe or NBOMe-2C-T as well as N-(2-methoxybenzyl)-4-methylthio-2,5-dimethoxyphenethylamine, is a serotonin 5-HT2 receptor agonist and possible serotonergic psychedelic of the phenethylamine, 2C, and 25-NB (NBOMe) families. It is the NBOMe (N-(2-methoxybenzyl)) derivative of 2C-T.
Interactions
Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 5-HT1B 3,385 5-HT1D 5-HT1E 5-HT1F 5-HT2A 0.54 (Ki)2.0–4.2 ()86–179% () 5-HT2B 0.91 (Ki) () () 5-HT2C 7.4 (Ki) (rat)21.4 ()103% () 5-HT3 5-HT4 5-HT5A 5-HT6 117 5-HT7 α1A–α1D α2A–α2C β1–β3 D1–D5 H1–H4 M1–M5 I1 σ1, σ2 (Ki) () () (Ki) () () (Ki) () () Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:
25T-NBOMe acts as a potent agonist of the serotonin 5-HT2A and 5-HT2C receptors and also shows interactions with certain other targets, such as the serotonin 5-HT2B receptor.
History 25T-NBOMe was first described in the scientific literature by 2010.
Society and culture Legal status Canada 25T-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 25-NB 25T2-NBOMe 25T4-NBOMe 25T7-NBOMe
References
External links 25T-NBOMe - Isomer Design