Márton Fucsovics defeated Botic van de Zandschulp in the final, 6–3, 7–6(7–3) to win the singles tennis title at the 2025 Winston-Salem Open. It was his third career ATP Tour title.
Lorenzo Sonego was the defending champion, but lost in the third round to Jaume Munar.
Seeds All seeds received a bye into the second round.
Draw
Finals
Top half Section 1
Section 2
Bottom half Section 3
Section 4
Qualifying Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw