During its history, Belgium has seen many families who have repeatedly produced notable politicians, and consequently such families have had a significant impact on politics in the Low Countries.

Anciaux Vic Anciaux (1931–2023) VU (Brussels State Secretary) Jan Anciaux (1958–) N-VA (Schepen in Vilvoorde) Bert Anciaux (1959–) sp.a (Flemish Minister, Senator) Koen Anciaux (1961–) Open Vld (Schepen in Mechelen) Roel Anciaux (1971–) sp.a (member of Flemish Brabant Provincial Council)

Coens (1938–1992) CVP (Flemish Minister) Joachim Coens (1966–) CD&V (Leader of CD&V)

de Brouckère Henri de Brouckère (1801–91) Lib. (Prime Minister of Belgium) Charles de Brouckère (1796–1860) Lib. (Minister of Finance, Interior and War)

De Croo Herman De Croo (1937–) VLD (Speaker of the Chamber, Minister of State) Alexander De Croo (1975–) Open Vld (Prime Minister of Belgium)

De Gucht Karel De Gucht (1954–) Open Vld (Minister of Foreign Affairs, European Commissioner) Frédéric De Gucht (1981–) Anders (Leader of Anders) Jean-Jacques De Gucht (1983–) Open Vld (Senator)

Dehousse Fernand Dehousse (1906–76) PS (Minister of Education) Jean-Maurice Dehousse (1936–2023) PS (Minister-President of Wallonia)

Eyskens Gaston Eyskens (1905–88) CVP (Prime Minister of Belgium) Mark Eyskens (1933–) CD&V (Prime Minister of Belgium)

Janson Paul Janson (1840–1913) Lib. (Senator)

Paul-Emile Janson (1872–1944) Lib. (Prime Minister of Belgium) Marie Janson (1873–1960) PSB (Senator)

Spaak Paul-Henri Spaak (1899–1972) PSB (Prime Minister of Belgium, Secretary General of NATO) Antoinette Spaak (1928–2020) FDF (Member of the European Parliament)

Simonet Henri Simonet (1931–96) PS (Minister of Economy and Foreign Affairs) Jacques Simonet (1963–2007) MR (Minister-President of the Brussels-Capital Region) Eléonore Simonet (1997–) MR (Minister of the Middle class, Self-Employed and SMEs)

Vanderpoorten Arthur Vanderpoorten (1884–1945) Lib. (Minister of Interior) Herman Vanderpoorten (1922–84) PVV (Minister of Interior and Justice) Marleen Vanderpoorten (1954–;) Open Vld (Minister of Education, Speaker of the Flemish Parliament)

Van Rompuy Herman Van Rompuy (1947–;) CD&V (President of the Chamber of Representatives, Prime Minister, President of the European Council) Peter Van Rompuy (1980–;) CD&V (Senator) Eric Van Rompuy (1949–;) CD&V (Minister of Agriculture and Economy)