MDTFEA, also known as 3,4-methylenedioxy-N-(2,2,2-trifluoroethyl)amphetamine, is a chemical compound and possible psychoactive drug of the phenethylamine, amphetamine, and MDxx families related to the entactogen MDEA. "I have been told of an analogue of MDE that has been synthesized, and explored by the researcher who synthesized it. It contains the N-trifluoroethyl group common to several pharmaceuticals such as Quazepam. The analogue is 3,4-methylenedioxy-N-(2,2,2-trifluoroethyl)amphetamine hydrochloride (mp 207–209 °C) which was made from 2,2,2-trifluoroethylamine and 3,4-methylenedioxyphenylacetone and sodium cyanoborohydride in methanol. The best final line for this compound is that it is “possibly active.” The most heroic dosage schedule mentioned was a total of 500 milligrams, taken in three approximately equal portions over the course of five or six hours, with only a very mild intoxication and little or no sympathomimetic effects. And what little there might have been was quickly gone." It is the derivative of MDEA in which the ethyl group on the amine has been replaced with a trifluoroethyl group.

Alexander Shulgin briefly described MDTFEA in his book PiHKAL (Phenethylamines I Have Known and Loved). Based on personal communication to Shulgin, it was described as "possibly active". The drug was tested at a highest total dose of 500mg orally, which was given in three divided doses over a period of 5 or 6hours. The effects included only a very mild intoxication and little or no sympathomimetic effects, with these possible effects being short-lasting. For comparison, MDEA has a listed dose of 100 to 200mg orally and a duration of 3 to 5hours. Daniel Trachsel has said that MDTFEA seems to be inactive.

The chemical synthesis of MDTFEA has been described.

MDTFEA was first described in the scientific literature by Shulgin in PiHKAL in 1991. It was not synthesized or tested by Shulgin but was instead described to him via personal communication.

See also Substituted methylenedioxyphenethylamine

References

External links MDTFEA - Isomer Design