RPE is a three letter acronym, which can refer to: Radiation protection expert Rapid palatal expander, an orthodontic device widen the palate Rating of perceived exertion, a scale for assessing perceived exertion during exercise IBM Rational Publishing Engine, a document generation solution Red Pine Elementary in Eagan, Minnesota, USA Respiratory protective equipment Retinal pigment epithelium — layer of the retina Revenue Per Employee, a ratio used to compare business efficiency Ribulose-phosphate epimerase, human gene for a protein that reversibly converts ribulose to xyulose Rocket Propulsion Establishment, UK-based military research site at RAF Westcott Russet Potato Exchange in Bancroft, Wisconsin, USA Radical Performance Engines a UK company that builds Race car and tuned Hayabusa Motorcycle Engines