LPE may refer to:

Lambda Pi Eta, a collegiate honor society the ICAO code for LAN Perú, the flag carrier airline in Peru, now LATAM Airlines Perú Lapeer (Amtrak station), a train station LimeWire Pirate Edition, file sharing software Lingenfelter Performance Engineering, a car modifier Liquid phase epitaxy, a semiconductor manufacturing process Liquid phase exfoliation, a method of processing chemical solutions Lone pair electrons, an atomic valence structure Local privilege escalation, a type of software exploit London Press Exchange, an advertising agency, merged with the Leo Burnett agency in 1969 Louisiana Purchase Exposition, the 1904 World's Fair in St. Louis, Missouri, to celebrate the centennial of the 1803 Louisiana Purchase Lysophosphatidylethanolamine, a type of organic chemical Longitude of the periapsis, a dimension of orbit Lepki language, of Western New Guinea