Twice in a Lifetime may refer to:
Twice in a Lifetime (TV series), a Canadian mystery/drama series Twice in a Lifetime (film), a 1985 film starring Gene Hackman Twice in a Lifetime (1974 film), a TV film starring Ernest Borgnine "Twice in a Lifetime", a song by Paul McCartney from The Paul McCartney Collection "Twice Inna Lifetime", a song by Black Star from Mos Def & Talib Kweli Are Black Star
See also Once in a Lifetime (disambiguation)