A mainframe computer is a type of large data processing system.
Mainframe may also refer to:
Mainframe Studios, a Canadian computer animation company founded as Mainframe Entertainment
Fictional entities Mainframe (comics), several Marvel Comics characters Mainframe (G.I. Joe), a character in the G.I. Joe universe Mainframe, a character from the game Gunman Chronicles Mainframe, the city in the animated series ReBoot Tina "Mainframe" Cassidy, a character from the animated TV series COPS Mainframe, a character in Gene Wolfe's series of novels The Book of the Long Sun