Rugambwa is a surname. Some notable people with this surname are:
Laurean Rugambwa (1912–1997), Tanzanian Catholic cardinal Novatus Rugambwa (1957–2025), Tanzanian Catholic archbishop and diplomat Protase Rugambwa (born 1960), Tanzanian Catholic cardinal
See also Cyprien and Daphrose Rugamba, victims of the 1994 Rwandan Genocide Dorcy Rugamba (born 1969), son of Cyprien and Daphrose, author, musician, actor, and dancer